Brief outline of the
neurochemistry of love
The areas that are involved are,
in the cortex, the medial insula, anterior cingulate, and hippocampus and, in
the subcortex, parts of the striatum and probably also the nucleus accumbens,
which together constitute core regions of the reward system. The passion of
love creates feelings of exhilaration and euphoria, of a happiness that is
often unbearable and certainly indescribable. And the areas that are activated in
response to romantic feelings are largely co-extensive with those brain regions
that contain high concentrations of a neuro-modulator that is associated with
reward, desire, addiction and euphoric states, namely dopamine. Like two other
modulators that are linked to romantic love, oxytocin and vasopressin (see
below), dopamine is released by the hypothalamus, a structure located deep in
the brain and functioning as a link between the nervous and endocrine systems.
These same regions become active when exogenous opioid drugs such as cocaine,
which themselves induce states of euphoria, are ingested. Release of dopamine
puts one in a ”feel good’’ state, and dopamine seems to be intimately linked not
only to the formation of relationships but also to sex, which consequently
comes to be regarded as a rewarding and “feel-good’’ exercise. An increase in
dopamine is coupled to a decrease in another neuro-modulator, serotonin (5-HT
or 5-hydroxytryptamine), which is linked to appetite and mood.
Studies have shown a depletion
of serotonin in early stages of romantic love to levels that are common in
patients with obsessive-compulsive disorders. Love, after all, is a kind of obsession
and in its early stages commonly immobilizes thought and channels it in the
direction of a single individual. The early stages of romantic love seem to
correlate as well with another substance, nerve growth factor, which has been
found to be elevated in those who have recently fallen in love compared to
those who are not in love or who have stable, long-lasting, relationships.
Moreover, the concentration of nerve growth factor appears to correlate significantly with the
intensity of romantic feelings.
Oxytocin and another
chemically linked neuro-modulator, vasopressin, seem to be particularly linked
to attachment and bonding. Both are produced by the hypothalamus and released
and stored in the pituitary gland, to be discharged into the blood, especially
during orgasm in both sexes and during child-birth and breast-feeding in
females. In males, vasopressin has also been linked to social behaviour, in
particular to aggression towards other males. The concentration of both neuro-modulators
increases during the phase of intense romantic attachment and pairing. The
receptors for both are distributed in many parts of the brain stem which are
activated during both romantic and maternal love.
It is noteworthy that sexual
arousal activates regions adjacent to – and in the case of the hypothalamus
overlapping with – the areas activated by romantic love, in the anterior cingulate
cortex, and in the other subcortical regions mentioned above. Especially
interesting in this regard is the activation of the hypothalamus with both
romantic feelings and sexual arousal, but not with maternal love. Its
activation may thus constitute the erotic component present in romantic, but
not in maternal attachment. Moreover, sexual arousal (and orgasms) de-activate
a region in the frontal cortex that over-laps the de-activated region observed
in romantic love. This is perhaps not surprising, given that humans often take
‘‘leave of their senses’’ during sexual arousal, perhaps even inducing them to
conduct which they might later, in more sober mood, regret. In fact, this
intimacy in terms of geographic location between brain areas engaged during
romantic love on the one hand and sexual arousal on the other is of more than
passing interest. Judged by the world literature of love, romantic love has at
its basis a concept – that of unity, a state in which, at the height of
passion, the desire of lovers is to be united to one another and to dissolve
all distance between them. Sexual union is as close as humans can get to
achieving that unity. It is perhaps not surprising to find, therefore,
that the areas engaged during these two separate but highly linked states are juxtaposed.
Indeed the desire for unity through sexual union may be a consequence of it.
Cortical de-activations and
the madness of love
It may seem surprising that
the face that launched a thousand ships did so through this limited set of
areas. But the story of Paris and Helen of Troy should in itself be enough to
tell us that these neurobiological results, viewed on their own, can lead to
deceptive interpretations. For romantic love is all-engaging, transforming
people’s lives and inducing them to both heroic and evil deeds. It is not
surprising to find
therefore that this core of brain areas that become engaged during romantic
love has rich connections with other sites in the brain, both cortical and
sub-cortical. Among these are connec-tions with the frontal, parietal and
middle temporal cortex as well as a large nucleus located at the apex of the
temporal lobe, known as the amygdala. Increase in activity in the romantic core
of areas is mirrored by a decrease in activity, or inactivation, of these
cortical zones. The amygdala is known to be engaged during fearful situations
and its de-activation, when subjects view pictures of their partners as well as
during human male ejaculation, implies a lessening of fear. As well, the all-engaging
passion of romantic love is mirrored by a suspension of judgment or a
relaxation of judgmental criteria by which we assess other people, a function
of the frontal cortex.
This cortical zone, along with
the parietal cortex and parts of the temporal lobe, has also been commonly
found to be involved in negative emotions. Its inactivation in romantic as well
as maternal states – when faced with the loved one – should not therefore be
surprising because, when deeply in love, we suspend those critical judgments
that we otherwise use to assess people. The prefrontal cortex, the
parieto-temporal junction and the temporal poles constitute a network of areas
invariably active with ‘mentalizing’ or ‘theory of mind’, that is, the ability
to determine other people’s emotions and intentions. It is noteworthy, from the
point of view of “unity-in-love’’, that one feature of mentalizing in terms of the
‘theory of mind’ is to distinguish between self and others, with the potential
of ascribing different
sets of beliefs and desires to others and to oneself. To obtain an imagined
‘‘unity-in-love’’, so that the self and the other are merged, this process of
mentalizing, and thus distinguishing between self and the other, must be
rendered inactive. But critical judgment of others is also often suspended with
the trust that develops between individuals and certainly with the deep bonding
that develops between a mother and her child. Here, then, is a neural basis not
only for saying that love is blind, but for the concept of ”unity-in-love’’. It
is not surprising that we are often surprised by the choice of partner that
someone makes, asking futilely whether they have taken leave of their senses.
In fact, they have. Love is often irrational because rational judgments are suspended
or no longer applied with the same rigour. In Plato’s Phaedrus, Socrates
comments: ‘‘the irrational desire that leads us toward the enjoyment of beauty
and overpowers the judgment that directs us toward what is right, and that is
victorious in leading us toward physical beauty when it is powerfully
strengthened by the desires related to it, takes its name from this very
strength and is called love’’. Nor are there moral strictures, for judgement in
moral matters is suspended as well.
After all, moral
considerations play a secondary role, if they play one at all, with Anna
Karenina, or Phedre, or Emma Bovary or Don Giovanni. And morality, too, has
been associated with activity of the frontal cortex.
Euphoria and suspension of
judgment can lead to states that others might interpret as madness. It is this
madness that poets and artists have celebrated, Plato considering it in
Phaedrus as a productive, desirable state because this kind of ‘‘madness comes
from God, whereas sober sense is merely human’’. But of course if it comes from
God, it transcends the world of rationality and is beyond the grasp of the
intellect or logos. Perhaps the neurological explanations, of a de-activation
of those parts of the brain that are involved in the making of judgments, makes
the frequent apparent irrationality of love more comprehensible. As Nietszche
once wrote, ‘‘There is always some madness in love. But there is always some
reason in madness’’, the reason to be sought in the pattern of neurobiological
activation and deactivation that romantic love entails, which serves the higher
purpose of uniting for biological purposes even unlikely pairs, and thus
enhancing variability. If ‘‘the heart has its reasons of which reason knows
nothing’’, it is quite literally, because reason is suspended. When Blaise
Pascal uttered these words he could not have known that reason is suspended
because the frontal lobes are (temporarily at least) also suspended. In fact,
we can draw a neurobiological lesson from this selective suspension of
judgment. For, if those in love suspend judgment about their lovers, they do
not necessarily as well suspended judgment about other things. They could, for
example, be perfectly able to judge the quality of a book or of a scientific work. They could
as well be perfectly able to have a theory of mind regarding persons other than
the one they love. The suspension of judgment is selective, and argues for a
very specific
set of connections and brain operations when it comes to love.
Neural correlates of maternal
love
Equally interesting is that
this pattern of areas activated by romantic yearnings shares parts of the brain
that also become active when mothers view pictures of their own children, as opposed
to other children. Maternal and romantic love share a common and crucial
evolutionary purpose, that of maintaining and promoting the species. They also
share a functional purpose, in that both require that individuals stay together
for a period of their lives. Both are thus calculated by nature to ensure the
formation of firm
bonds between individuals, by making of them rewarding experiences. It is not surprising
to find
that both sentiments share common brain areas. But, given the neurological
axiom stated above, that if you can tell the difference it is because different brain areas are
involved, it is also not surprising to find that the pattern of brain
activation that correlates with maternal love is not identical to the one that
correlates with romantic love. An interesting difference lies in the strong
activation of parts of the brain that are specific for faces in maternal love.
This may be accounted for by the importance of reading children’s facial
expressions, to ensure their well being, and therefore the constant attention
that a mother pays to the face of her child.
Another interesting difference is that the
hypothalamus, which is associated to sexual arousal, is only involved in
romantic love. The commonly activated regions between the two types of love are
located in the striatum, part of the reward system of the human brain. It is
also true that in maternal love, no less than in romantic love, judgment is
somewhat suspended, in that mothers are a good deal more indulgent with their
children and perhaps less likely to fault them. Once again, we find that there is a
pattern of cortical de-activation produced by maternal love which is remarkably
similar to the one produced by romantic love and in particular the frontal cortex
that is involved in the formation of judgments.
Brain concepts of the lover
It is a truism to say that
most people develop a preference for the kind of person they want to love, and
hence a concept of their potential lover(s); their likelihood of falling in
love with that kind of person is that much greater. These preferences come in
many different
forms and are almost certainly conditioned by, among other things, parental influences, cultural
predelictions and the kind of person that they may have met. A recent study has
in fact charted the ‘‘average’’ man with whom women are most likely to fall in
love. He is smooth-skinned and remote from the kind of macho type that many believe
are attractive to women. The characteristics associated with the most desirable
(virtual) man are not only linked to sexual attractiveness but also ones that
suggest a caring attitude. Clearly, this average man, chosen by female students
at St Andrews University in Scotland, is the result of a concept and may apply
only to the environment in which the study was conducted. The importance of the
study lies in showing us that we do indeed form a concept of the kind of person
we would like to love. In the literature of love, perhaps nowhere is this more
emphatically stated than in the work of Dante, whose love for Beatrice is one
of the most celebrated love affairs
in the Western literature. Yet Dante stated quite clearly in his first work, La Vita
Nuova (The New Life), that what he really wanted to write about was not about
Beatrice (who was dead by then) but about ‘‘lo gloriosa donna de la mia mente’’
(the glorious lady of my mind).
In matters of love and
attachment, we can go a little further and sketch in outline form the chemistry
that underlies the concept of the loved one that the brain forms.
Unfortunately, we cannot do so for man yet but for much simpler animals, the prairie
voles, rats, mice, marmosets and monkeys. But it would be hard to believe that
similar, though almost certainly infinitely more complex mechanisms, do
not operate in humans.
Perhaps the first step in this
enquiry is to look at the chemistry of the human brain areas that are activated
during romantic love, and in particular oxytocin, vasopressin and dopamine.
Most brain regions, including subcortical regions, that have been determined to
contain receptors for oxytocin and vasopressin are activated by both romantic
and maternal love. To better understand the role of these chemicals in bonding,
we have to rely on recent experiments on prairie voles.
Oxytocin and vasopressin have
many effects
but most relevant from our point of view is that, not only are they involved in
bonding between individuals but have also been found to be effective in learning
and memory, but only in a social context. Both are released when prairie voles
have sex. They are intimately linked to dopamine, which is associated with
reward. And although prairie voles are a long way from man, the release of
these hormones in other animals, including man, under similar conditions makes
it likely that their human counter-parts are also strongly involved in
activities associated with romantic and maternal love, which is not to say that
these are their only functions. The story of voles is actually of great biological
interest, especially when one contrasts two species, the prairie and the
montane vole, the former having monogamous relationships (with the occasional fling thrown in) and
the latter indulging in promiscuous sex without long-term attachment. If the
release of these two hormones is blocked in prairie voles, they too become
promiscuous. If, however, prairie voles are injected with these hormones but
prevented from having sex, they will continue to be faithful to their partners,
that is to have a monogamous though chaste relationship. One might have
imagined that injection of these hormones into the promiscuous montane voles
would make of them virtuous, monogamous, animals too. But that is not how
things work out and injection of these hormones into montane voles does not
render them monogamous. This may seem at first paradoxical, but there is a
simple biological way of accounting for it and it is of substantial interest in
the context of concept formation.
Once secreted by the
pituitary, these neuro-hormones can only act if there are receptors for them.
In the prairie vole there is an abundance of receptors for vasopressin and
oxytocin in the reward centres of the brain. These centres are not clearly defined as yet but
include many structures that have been found to be active in reward conditions.
Many are located in the sub-cortex. Receptors for oxytocin and vasopressin are missing
or not as abundant in the reward centres of the montane voles. Hence injecting
montane voles with a surplus of these two neuro-hormones does not make them
monogamous, since there are not sufficient receptors for them in the
reward centres. It is as if these two hormones, strongly implicated from other
evidence with bonding, are the ones that keep voles faithful and monogamous and
as if the absence of receptors for them makes of their relatives promiscuous
animals. There is no evidence that these two neuro-hormones act in the same way
in humans; it would be surprising if they did, given the infinitely more
complicated structure of the human brain. But it would not be surprising if we find in the vole a
vestigial system to account for the sexual and romantic nature of humans.
Mankind is often, but very mistakenly, considered to be monogamous. The
evidence from divorce rates, adultery and other more or less clandestine and
casual encounters, as well as the flourishing trade in prostitution and
pornography, suggests otherwise, which is not to say that many among the human
race do not maintain monogamous, or serially monogamous, relationships. It
would be highly interesting to learn whether monogamous humans have a higher
concentration of oxytocin and vasopressin, as well as a richer concentration of
receptors for them in the reward centres of the human brain compared to their
more promiscuous counterparts. One might even find that humans can be divided
into three or more categories –ranging from the extremely promiscuous to the
strictly monogamous, and that this distribution reflects the
distribution of receptors for vasopressin and oxytocin, which is known to vary in
species as far apart as voles and humans.
Oxytocin and vasopressin seem
to play a crucial role in forming a concept of the kind of partner that an
organism wants to be with, at least in the world of vole ideas. They appear to
do so by building a strong profile
of the mating partner through odour and, once they do so, the odour-derived concept
seems to be very stable. The odour comes to be associated with a pleasurable
and rewarding encounter with a particular partner. The same works in the visual
domain, as has been shown in sheep – once oxytocin is released in the presence
of a baby, the sheep will visually recognise the baby and behave in a motherly
way toward it until it is grown up. If the gene for either of these two
neuro-modulators is disabled before birth by genetic engineering in a mouse,
the mouse will no longer be able to form a profile – or a concept – of the
mice that it meets. It becomes totally amnesic in this regard and hence
promiscuous. It is not outrageous to suggest that this neurochemically mediated
experience has all the hallmarks of concept formation, though concept formation
at a very elementary, chemical, level. The concept formed is that of an individual;
it is based on an encounter and sexual experience, is acquired postnatally and
is associated with a pleasurable, rewarding, experience with a partner of a
particular odour.
Love and beauty
A beautiful person, as is
commonly known, is perhaps the surest way of evoking the sentiment of love.
Throughout history, from the days of Plato onwards, the path to love has been described
as being through beauty. Dante falls in love with Beatrice because he finds her beautiful,
and longs to see that which is hidden in her physique. The Lord Krishna
‘‘steals the mind’’ with his beauty and Majnun, in his love for Leila, is
obsessed by her beauty, even if she does not seem beautiful to others. ‘‘To see
her beauty’’, he declares, ‘‘you must borrow my eyes’’. Beauty and love are
themselves never far from erotic desire, since the most intense love is
strongly coupled to sexual desire and the two faculties share common areas in
the brain, as described above. It is not surprising to find therefore that
an attractive face and sexual arousal, as well as the experience of visual
beauty, engage a part of the brain known as the orbito-frontal cortex. Nor is
this the only common brain region engaged by the two aspects of romantic love.
The face of a loved person engages two cortical regions, the insula and the
anterior cingulate, as do sexually arousing visual stimuli.
Attractive faces, as well as
the faces of a loved person, de-activate not only the frontal cortex but also
the amygdala (mentioned above), which is also de-activated when viewing the face
of a loved person. This suggests that not only is judgmentless severe when
looking at a loved or desired person, but that the curiosity and apprehension
with which we often survey faces for discomfiting signs are suspended. Moreover,
the orbito-frontal cortex is connected with the amygdala and with other
cortical areas and sub-cortical areas – the anterior cingulate cortex, the
putamen and the caudate – that are engaged during the experience of romantic
love. Hence the intimate experiential connection between love and beauty is
probably nothing more than an expression of the intimate anatomical connection
between the centres that are involved in these two experiences. So intimate
must the anatomical link between them be that the experiences themselves become
difficult
to disentangle.